list of existing BSL-4 facilities worldwide

Name
Location
Date established
Description

[1] National Service of Healthcare and Agriculture Quality (SENASA), Buenos Aires,
Argentina Diagnostic laboratory for Foot-and-mouth disease.

[2] Australian Animal Health Laboratory; Geelong, Victoria, Australia; 1985; Capable of housing from large experimental animals to insects under conditions that exceed all BSL 4 requirements. The antecedent of all such facilities developed since the 1980's. Arguably the most researched design and construction project ever. AAHL is subdivided into a number of isolation zones that can be managed at differing containment levels concurrently. CSIRO AAHL Project Manager and Architect, William Curnow, provided technical reviews to Canadian, Indian, UK and French Authorities and consulted with Dr Jerry Callis [PIADC] to UN FAO on matters of bio-containment.University of Melbourne – Doherty Institute for Infection and Immunity Melbourne, Victoria, Australia 2014 Diagnostic reference lab.

[3] National High Security LaboratoryMelbourne, Victoria, AustraliaOperates under the auspice of the Victoria Infectious Diseases Reference Laboratory.

[4] Laboratório Nacional Agropecuário de Minas Gerais (Lanagro/MG) Pedro Leopoldo, Minas Gerais, Brazil; 2014; Focus on Agropecuary diseases and diagnostics.

[5] National Microbiology Laboratory Winnipeg, Manitoba, Canada. Located at the Canadian Science Centre for Human and Animal Health, it is jointly operated by the Public Health Agency of Canada and the Canadian Food Inspection Agency.

[6] Wuhan Institute of Virology of the Chinese Academy of Sciences Wuhan, Hubei, China; 2015; Wuhan Institute of Virology has existed since 1956 and already hosted BSL3 laboratories. A BSL4 facility was completed in 2015, and became the first, only and visible BSL-4 laboratory in China.

[7] Biological Defense Center Těchonín, Pardubice Region, Czech Republic;1971; rebuilt 2003-2007. Hospital and research facility. Located at the Centrum biologické ochrany (Biological Defense Center). Operated by Army of the Czech Republic.

[8] Jean Mérieux BSL-4 LaboratoryLyon, Metropolis of Lyon, France1999Built and owned by the Fondation Mérieux. Since 2004, operated by INSERM.

[9] Laboratoire de la DGAVert-le-Petit, Essonne, France; 2013; Operated by the Ministry of Defense.

[10] Centre International de Recherches Médicales de Franceville Franceville, Haut-Ogooué Province, Gabon. This facility is operated by a research organization supported by both Gabonese (mainly) and French governments, and is West Africa's only P4 lab (BSL-4).

[11 ] Robert Koch InstituteBerlin, Germany; 2015; Diagnostic and experimental lab facility.

[36] Bernhard Nocht Institute for Tropical MedicineHamburg, Germany; 2014; Part of the Leibniz Center Infection. National reference lab for tropical viruses.

[12] Friedrich Loeffler InstituteIsle of Riems, Greifswald, Mecklenburg-Vorpommern, Germany2010Focus on animal viral diseases and diagnostics.

[13] Philipps University of Marburg Marburg, Hesse, Germany; 2008; Focuses on hemorrhagic fever viruses.

[14] Országos Epidemiológiai Központ – National Center for EpidemiologyBudapest, Hungary1998Division of Virology operates three WHO National Reference Laboratories. The BSL-4 biosafety laboratory provides a modern means to process dangerous imported zoonotic viral pathogens.

[15] University of PécsPécs, Hungary2016Opened in 2016, part of "Szentágothai János Kutatóközpont".High Security Animal Disease Laboratory (HSADL)Bhopal, Madhya Pradesh, India1998This facility deals especially to zoonotic organisms and emerging infectious disease threats.

[17] Centre for Cellular and Molecular BiologyHyderabad, Telangana, India2009National BSL-4 Containment Facility for Human Infectious Diseases.

[18] National Institute of VirologyPune, Maharashtra, India2012India's first BSL4 lab and the most advanced.

[19] Istituto Nazionale per le Malattie InfettiveRome, Lazio, Italy1997The "National Institute of Infectious Diseases" used to operate within the Lazzaro Spallanzani hospital; the facility is now independent and is home to five BSL-3 labs as well as a single BSL-4 laboratory, which was completed in 1997.

[20] National Institute for Infectious DiseasesMusashimurayama, Tokyo, Japan2015Located at National Institute for Infectious Diseases, Department of Virology I. Built in 1981; operated at BSL-3 until 2015 due to opposition from nearby residents.

[21] Institute of Physical and Chemical Research (RIKEN)Tsukuba, Ibaraki Prefecture, Japan1984Facility completed in 1984 but not operated as BSL-4 due to local opposition.

[22] State Research Center of Virology and Biotechnology (VECTOR)Koltsovo, Novosibirsk Oblast, RussiaOne of two WHO-approved facilities for work on variola virus.[14]National Institute for Communicable DiseasesJohannesburg, Gauteng, South Africa2002

[23] Public Health Agency of SwedenSolna, Stockholm County, Sweden2001The only BSL-4 facility in the Nordic region. Constructed for research and diagnostics of hemorrhagic fever viruses.

[24] University Hospital of GenevaGeneva, Canton of Geneva, Switzerland"Glove box" type laboratory; primarily for handling clinical samples.

[25] Spiez LaboratorySpiez, Canton of Bern, Switzerland2013Run by Federal Office for Civil Protection and the Federal Department of Defence, Civil Protection and Sports.

[26] Institute of Medical VirologyZurich, Canton of Zurich, SwitzerlandPart of the University of Zurich. Primary purpose is diagnostics of highly pathogenic viruses.

[27] Institute of Preventive MedicineNational Defense University, Taiwan; 1983

[28] Francis Crick InstituteCamden, Greater London, United Kingdom2015Has BSL-4 space but does not work on human pathogens.

[29] Health Protection Agency's Centre for InfectionsColindale, Greater London, United KingdomDepartment of Health laboratory. Diagnostics for various viral diseases.

[30] Part of the European Network of Biosafety-Level-4 Laboratories.[54]National Institute for Medical ResearchMill Hill, Greater London, United KingdomMedical Research Council laboratory. Research and diagnostics for highly pathogenic viruses. Closed in 2017 and work moved to the Francis Crick Institute. Site demolished in 2018.

[31] National Institute for Biological Standards and ControlPotters Bar, Hertfordshire, United KingdomDepartment of Health and Home Office laboratory. Develop assays and reagents for research on virulent pathogens.

[32] Veterinary Laboratories Agency Addlestone, Surrey, United Kingdom Department for Environment, Food and Rural Affairs laboratory. Diagnostics and research for animal diseases.

[33] Institute for Animal HealthPirbright, Surrey, United KingdomBiotechnology and Biological Sciences Research Council laboratory. Research on highly pathogenic animal diseases.

[34] Merial Animal HealthPirbright, Surrey, United KingdomPrivate lab. Produces vaccines against foot and mouth disease and bluetongue disease.

[35] Centre for Emergency Preparedness and Response Porton Down, Wiltshire, United KingdomDepartment of Health laboratory. Diagnostics and research for haemorrhagic fever viruses.

[36] Part of the European Network of Biosafety-Level-4 Laboratories.

[37] Defence Science and Technology LaboratoryPorton Down, Wiltshire, United KingdomMinistry of Defence laboratory. Focuses on protection from biological weapons.

[38] Centers for Disease Control and Prevention, Division of Vector Borne DiseasesFort Collins, Colorado, United StatesA BSL 3/4 facility that operates in connection with some of CSU's biomedical research programs. The Fort Collins, Colorado location specializes in arboviral and bacterial diseases.

[39] Centers for Disease Control and PreventionAtlanta, Georgia, United StatesCurrently operates in two buildings. One of two facilities in the world that officially hold smallpox.[14]Georgia State UniversityAtlanta, Georgia, United States1997Research focus on B virus.

[40] National Bio and Agro-Defense Facility (NBAF), Kansas State UniversityManhattan, Kansas, United States2022 (expected)Under construction. Facility to be operated by the Department of Homeland Security, and replace the Plum Island Animal Disease Center. Expected to be operational by 2022-2023.

[41] National Institutes of Health (NIH)Bethesda, Maryland, United StatesLocated on the NIH Campus, it currently only operates with BSL-3 agents.

[42] Integrated Research FacilityFort Detrick, Maryland, United StatesOperated by NIAID. Focuses on animal models of human diseases.

[43] National Biodefense Analysis and Countermeasures CenterFort Detrick, Maryland, United StatesOperated by the Department of Homeland Security. Focus on potential bioterrorism threats.

[44] US Army Medical Research Institute of Infectious Diseases (USAMRIID) Fort Detrick, Maryland, United States; 1969; Run by the U.S. Army. Research focuses on biological threats to the U.S. military.

[45] National Emerging Infectious Diseases Laboratory (NEIDL), Boston UniversityBoston, Massachusetts, United StatesBuilt 2008, Opened 2012; BSL-4 Approval in 2017; Focus on potential threats to public health.

[46] Rocky Mountain LaboratoriesHamilton, Montana, United States; 1928; NIAID laboratory. Focus on vector-borne diseases.

[47] Galveston National Laboratory, National Biocontainment FacilityGalveston, Texas, United StatesOpened in 2008, facility is operated by the University of Texas Medical Branch.

[48] Shope Laboratory Galveston, Texas, United States; 2004; Operated by the University of Texas Medical Branch.

[49] Texas Biomedical Research InstituteSan Antonio, Texas, United States1999The only privately owned BSL-4 lab in the US.

[50] Osong Laboratory Osong, North Chungcheong Province, South Korea; 2017 First BSL-4 Lab in South Korea.